ghPremier League

From Tarkwa, champions of the 2025/26 season (their 2nd title), qualifying for the CAF Champions League.

From Bibiani, nicknamed "the Miners", narrow runners-up in 2025/26.

From Accra, the most successful club in Ghanaian football history and traditional rival of Asante Kotoko.

From Dawu, FA Cup winners in 2022/23, finished fourth in 2025/26.

From Dormaa Ahenkro in the Bono Region, two-time league champions.

From Samreboi, defending the 2023/24 title, backed by a timber company.

From Aiyinase, the first club from the Nzema region to reach the Ghanaian top flight, in 2017.

From the town of Berekum in the Bono Region.

From the port city of Tema, a newer club settled in mid-table.

From Kumasi, record 24-time Ghanaian champions and two-time CAF Champions League winners, nicknamed the "Porcupine Warriors".

From Agona Swedru, back in the top flight after 16 years away.

From Wenchi in the Bono Region, founded in 2012.

From Kumasi, winners of the 2026 Ghana FA Cup, nicknamed "the Pride of Bosomtwe".

From the Ahafo Region, nicknamed "the Hunters", made their CAF Confederation Cup debut.

From Nzema-Basake in the Western Region, a club focused on developing young talent.

From Kpando in the Volta Region, relegated after the 2025/26 season.

From Hohoe in the Volta Region, withdrew mid-season in 2025/26 amid disputes over officiating.

From Techiman, nicknamed "the Sure Wonders", relegated after a poor 2025/26 campaign.